Zinc-doped hydroxyapatite-zeolite/polycaprolactone composites coating on magnesium substrate for enhancing in-vitro corrosion and antibacterial performance
(1. Biomedical Engineering Centre, University of Engineering and Technology,
Kala Shah Kaku (KSK) Campus, Lahore, Pakistan;
2. Department of Physics, University of the Punjab, Quaid-e-Azam Campus, Labore, Pakistan;
3. Department of Chemical Polymer & Composite Material Engineering,
University of Engineering and Technology, Kala Shah Kaku (KSK) New Campus, Lahore, Pakistan;
4. Advanced Materials Research Center, Department of Materials Engineering,
Najafabad Branch, Islamic Azad University, Najafabad, Iran;
5. School of Mechanical Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Johor, Malaysia;
6. Kulliyyah of Science, International Islamic University Malaysia, Bandar Indera Mahkota Campus,
Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang Darul Makmur, Malaysia;
7. School of Biomedical Engineering and Health Sciences, Faculty of Engineering,
Universiti Teknologi Malaysia, Johor, Malaysia;
8. Tissue Engineering Group (TEG),
National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL),
Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya,
50603 Lembah Pantai, Kuala Lumpur, Malaysia)
Kala Shah Kaku (KSK) Campus, Lahore, Pakistan;
2. Department of Physics, University of the Punjab, Quaid-e-Azam Campus, Labore, Pakistan;
3. Department of Chemical Polymer & Composite Material Engineering,
University of Engineering and Technology, Kala Shah Kaku (KSK) New Campus, Lahore, Pakistan;
4. Advanced Materials Research Center, Department of Materials Engineering,
Najafabad Branch, Islamic Azad University, Najafabad, Iran;
5. School of Mechanical Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, Johor, Malaysia;
6. Kulliyyah of Science, International Islamic University Malaysia, Bandar Indera Mahkota Campus,
Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang Darul Makmur, Malaysia;
7. School of Biomedical Engineering and Health Sciences, Faculty of Engineering,
Universiti Teknologi Malaysia, Johor, Malaysia;
8. Tissue Engineering Group (TEG),
National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL),
Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya,
50603 Lembah Pantai, Kuala Lumpur, Malaysia)
Abstract: This work is focused on developing zinc-doped hydroxyapatite-zeolite (ZnHA-Zeo) and polycaprolactone (PCL) composite coatings on magnesium (Mg) substrate to improve the corrosion resistance and antimicrobial properties. Dip-coating technique was used to coat ZnHA-Zeo/PCL on the Mg substrate at room temperature. The samples were subjected to field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), energy dispersive X-ray spectroscopy (EDX) and antimicrobial potential. Results demonstrated that composite coatings consist of HA, scholzite, zeolite, and PCL phases. EDX spectra indicated the presence of calcium (Ca), silicon (Si), aluminum (Al), zinc (Zn), phosphorus (P) and oxygen (O). The composite surface appeared in spherical-like microstructure on coating with thickness ranging 226-260 μm. Zinc-doped HA-Zeo composite coating had a high corrosion resistance and provided sufficient protection to the Mg surface against galvanic corrosion. Doped ZnHA-Zeo coating samples exhibited superior disc inhibition by confirming antimicrobial activity against the E. coli as compared to HA-Zeo sample. Altogether these results showed that the ZnHA-Zeo coatings not only improved the corrosion resistance, but also enhanced the antimicrobial property and hence they can be used as suitable candidates for implant applications.
Key words: biodegradable magnesium; bioceramics coating; corrosion resistance; antimicrobial activity