In vitro biocompatibility of titanium-nickel alloy with titanium oxide film by H2O2 oxidation
(1. School of Materials Science and Engineering, Southeast University,
Nanjing 211189, China;
2. School of Public Health, Southeast University, Nanjing 210096, China;
3. Department of Physics and Materials Science, City University of Hong Kong,
Hong Kong, China)
Nanjing 211189, China;
2. School of Public Health, Southeast University, Nanjing 210096, China;
3. Department of Physics and Materials Science, City University of Hong Kong,
Hong Kong, China)
Abstract: Titanium oxide film with a graded interface to NiTi matrix was synthesized in situ on NiTi shape memory alloy(SMA) by oxidation in H2O2 solution. In vitro studies including contact angle measurement, hemolysis, MTT cytotoxicity and cell morphology tests were employed to investigate the biocompatibility of the H2O2-oxidized NiTi SMAs with this titanium oxide film. The results reveal that wettability, blood compatibility and fibroblasts compatibility of NiTi SMA are improved by the coating of titanium oxide film through H2O2 oxidation treatment.
Key words: NiTi shape memory alloy; titanium oxide film; biocompatibility; wettability; cytocompatibility