An impedance response model for inhibitory effect of antibiotics
on bacterial growth in biometallurgy①
on bacterial growth in biometallurgy①
(State Key Laboratory of Chemo/Biosensoring and Chemometrics,
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China)
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China)
Abstract: An impedance response model reflecting the inhibitory effect of antibiotics on bacterial growth in biometallurgy was established. Three inhibition parameters, i.e. the maximum amount inhibitory constant of the bacterial growth (K1), the maximum specific growth inhibitory constant(K2) and the lag time inhibitory constant(K3), were included in the model. The influence of these parameters on the response curve was discussed in detail. By fitting experimental data
towards the proposed model, three growth parameters (A,μmandλ) in the presence of antibiotics were gained and compared. The results show that the growth ability of bacteria is decreased due to the influence of antibiotics. The experimental and fitted curves have goodness-of-fit in the range of 0.987 1.008. Moreover, the kinetic growth parameters obtained from this model are closed to those from the Logistics popular growth model. These results show that the proposed model is validity to reflect the inhibitory effect of antibiotics on bacteria.
towards the proposed model, three growth parameters (A,μmandλ) in the presence of antibiotics were gained and compared. The results show that the growth ability of bacteria is decreased due to the influence of antibiotics. The experimental and fitted curves have goodness-of-fit in the range of 0.987 1.008. Moreover, the kinetic growth parameters obtained from this model are closed to those from the Logistics popular growth model. These results show that the proposed model is validity to reflect the inhibitory effect of antibiotics on bacteria.
Key words: impedance response model; Logistics popular growth model; inhibitory parameters ; taphylococcus aureus; antibiotics