Mechanism of anti-arterial thrombosis of Dahuangzhecong Fang screened by Ti-Al intermetallic compound porous material
(1. Xiangya Hospital, Central South University, Changsha 410008, China;
2. Henan Yuzhou Chinese Medicine Hospital, Yuzhou 461670, China;
3. Hunan Traditional Chinese Medicine University, Changsha 410208, China;
4. State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China)
2. Henan Yuzhou Chinese Medicine Hospital, Yuzhou 461670, China;
3. Hunan Traditional Chinese Medicine University, Changsha 410208, China;
4. State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China)
Abstract: The mechanism of antithrombotic of Dahuangzhechong Fang separated and purified by Ti-Al intermetallic compound porous material (TAICPM) was researched. Dahuangzhechong Fang, which was isolated and screened by TAICPM, was used to oral rats. At the end of study, their blood and thrombus were collected. The results show that TAICPM with the pore size of 1-5 μm can screen Dahuangzhechong Fang well. Dahuangzhechong Fang can increase 6-keto-PGF1α, lower content of TXD2 and platelet. Dahuangzhechong Fang has good effect to resist arterial thrombosis.
Key words: Ti-Al intermetallic compound porous materials; Dahuangzhecong Fang; arterial thrombosis; isolated Chinese medicine