Biocompatibility and preliminary clinical application of HA/HDPE nanocomposites synthetic auditory ossicle
(1.2. Transplantation Medical Academy, The Third Xiang-Ya Hospital, Central South University, Changsha 410013, China2.湖南省长沙市中南工业大学粉末冶金国家重点实验室3.State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China4.中南大学 粉末冶金国家重点实验室，长沙 410083)
Abstract: The biocompatibility of the hydroxyapatite/high density polyethtlene(HA/HDPE) nanocomposites synthetic auditory ossicle was evaluated, the percentage of S-period cells was detected by flow cytometry after L929 incubated with extraction of the HA/HDPE nanocomposites, titanium materials of clinical application as the control. Both of them were implanted in the animals and the histopathological evaluations were carried out, and the preliminary clinical trials about HA/HDPE nanocomposites synthetic auditory ossicles were also carried out. The statistical analysis show that there are no statistically significant differences between HA/HDPE test groups and control groups (P＞0.05), which demonstrates that the HA/HDPE nanocomposites synthetic auditory ossicle has a good biocompatibility and clinical application outlook.
Key words: hydroxyapatite; high density polyethtlene; ossicle; biocompatibility; flow cytometry