ISSN: 1003-6326
CN: 43-1239/TG
CODEN: TNMCEW

Vol. 33    No. 5    May 2023

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Bioactive coating with antibacterial and anticorrosive properties deposited on ZA6-1 alloy bone implant
De-ren ZHAO1,2, Dong CHEN3, Xue FENG4, Zi-lin CHEN1,2, Chen JIN1,2, Xiao-dong TAN1,2, Yun-jie XIANG1,2, Wen-bo JIAO1,2, Ya-xing FANG1,2, Li-qun XU1,2, Yong-ping ZHANG1,2, Xi RAO1,2
(1. School of Materials and Energy, Southwest University, Chongqing 400715, China;
2. Chongqing Key Laboratory of Soft-matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715, China;
3. School of Food Science, Southwest University, Chongqing 400715, China;
4. Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China
)
Abstract: The commercial zinc aluminum alloy (ZA6-1) surface was functionalized with poly-(lactic-co-glycolic) acid (PLGA) containing sodium dodecyl sulfate (SDS) and levulinic acid (LA) for gaining antibacterial activity. A polymerized 3-aminopropyltriethoxysilane (APTES) layer was initially fabricated on the surface of ZA6-1 alloy to gain amino group, and the PLGA mixed with SDS/LA was subsequently immobilized on the as-treated surface through the electrostatic interaction between amino group and carboxyl group. The PLGA-SDS/LA coating on zinc alloy showed extremely good corrosion resistance with the degradation rate of 0.005 mm/a, which can be adjusted by varying the coating thickness. Furthermore, besides the good biocompatibility to osteoblasts, the PLGA-SDS/LA coating exhibited excellent antibacterial property, and the bactericidal rates against Staphylococcus aureus and Escherichia coli were 98.9% and 99.8%, respectively.
Key words: zinc alloy; polymer coating; antibacterial property; biocompatibility; corrosion behavior
Superintended by The China Association for Science and Technology (CAST)
Sponsored by The Nonferrous Metals Society of China (NFSOC)
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