By combining the mass transfer mechanism of neodymium oxide with dissolution kinetics, a solution strategy for neodymium oxide dissolution was proposed to predict the dissolved neodymium oxide concentration during the process under complex flow field conditions. The factors affecting neodymium oxide dissolution were analyzed in detail. Aiming at the pulse feeding and continuous feeding modes in industrial practice, the characteristics of the dissolution process under the two feeding modes were compared. Simulation results showed that pulse feeding took shorter time to distribute evenly than continuous feeding. Finally, the dissolution time of single-particle neodymium oxide under static flow field conditions was compared with the literature results. Except for only one set of data with a maximum error of about 10%, the errors of other data are all within 5%.