Bioactive coating with antibacterial and anticorrosive properties deposited on ZA6-1 alloy bone implant

De-renZHAO,DongCHEN,XueFENG,Zi-linCHEN,ChenJIN,Xiao-dongTAN,Yun-jieXIANG,Wen-boJIAO,Ya-xingFANG,Li-qunXU,Yong-pingZHANG,XiRAO,

doi:10.1016/S1003-6326(23)66199-0

Transactions of Nonferrous Metals Society of China >

2023 , Vol. 33 >Issue 5: 1507 - 1521

DOI: https://doi.org/10.1016/S1003-6326(23)66199-0

Materials Science and Engineering

Bioactive coating with antibacterial and anticorrosive properties deposited on ZA6-1 alloy bone implant

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De-ren ZHAO^1,2, Dong CHEN³, Xue FENG⁴, Zi-lin CHEN^1,2, Chen JIN^1,2, Xiao-dong TAN^1,2, Yun-jie XIANG^1,2, Wen-bo JIAO^1,2, Ya-xing FANG^1,2, Li-qun XU^1,2, Yong-ping ZHANG^1,2, Xi RAO^1,2

1. School of Materials and Energy, Southwest University, Chongqing 400715, China;
2. Chongqing Key Laboratory of Soft-matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing 400715, China;
3. School of Food Science, Southwest University, Chongqing 400715, China;
4. Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China

Online published: 2023-05-25

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Abstract

The commercial zinc aluminum alloy (ZA6-1) surface was functionalized with poly-(lactic-co-glycolic) acid (PLGA) containing sodium dodecyl sulfate (SDS) and levulinic acid (LA) for gaining antibacterial activity. A polymerized 3-aminopropyltriethoxysilane (APTES) layer was initially fabricated on the surface of ZA6-1 alloy to gain amino group, and the PLGA mixed with SDS/LA was subsequently immobilized on the as-treated surface through the electrostatic interaction between amino group and carboxyl group. The PLGA-SDS/LA coating on zinc alloy showed extremely good corrosion resistance with the degradation rate of 0.005 mm/a, which can be adjusted by varying the coating thickness. Furthermore, besides the good biocompatibility to osteoblasts, the PLGA-SDS/LA coating exhibited excellent antibacterial property, and the bactericidal rates against Staphylococcus aureus and Escherichia coli were 98.9% and 99.8%, respectively.

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De-renZHAO,DongCHEN,XueFENG,Zi-linCHEN,ChenJIN,Xiao-dongTAN,Yun-jieXIANG,Wen-boJIAO,Ya-xingFANG,Li-qunXU,Yong-pingZHANG,XiRAO, . Bioactive coating with antibacterial and anticorrosive properties deposited on ZA6-1 alloy bone implant[J]. Transactions of Nonferrous Metals Society of China, 2023 , 33(5) : 1507 -1521 . DOI: 10.1016/S1003-6326(23)66199-0

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