The multi-scale simulation of flow behavior and microstructure evolution of 2219 aluminum alloy during ring rolling was conducted. A new forming technology with two-stage hot-warm ring rolling was proposed compared to conventional hot rolling. The results show that the distributions of temperature, strain and strain rate are inhomogeneous on the cross section. The grains of edge nodes are elongated resulting from the larger strain and the low-angle grain boundaries transform into high-angle grain boundaries resulting in the increased fraction of recrystallization in hot rolling. The elongated banded structures change to equiaxed grains during the solution treatment, indicating complete static recrystallization. The inhomogeneous distributions of the temperature and strain result in heterogeneous microstructure distribution. The rolling force and the geometry of the ring were analyzed with experiment. The tensile properties in all directions of the ring and its isotropy are significantly increased with the new technology, especially the elongation.