The interfacial heat transfer coefficient (IHTC) values of 7075 aluminum alloy in contact solid solution treatment process at different pressures, surface roughnesses and temperatures were determined by using finite element (FE) simulation and inversion optimization (IO) method, and the effects of these factors on IHTC were analyzed. The results showed that the IHTC value first increased with the increase of pressure and then remained stable. The IHTC value decreased with the increase of surface roughness. The instantaneous IHTC value first increased and then decreased with increasing the plate temperature. Based on the integrating phenomenological laws of pressure, surface roughness and temperature, a multifactorial-influenced IHTC prediction model was established. It could be used to well predict the instantaneous IHTC value of the alloy under different conditions.