The equiatomic and equimass TiHfMo, TiHfMoNb and TiHfMoNbZr alloys were prepared, and their microstructure, mechanical properties and bio-corrosion behaviors were systematically investigated. The results demonstrated that all the multi-principal element alloys (MPEAs) had a single BCC phase structure without any intermetallic compounds. Moreover, the Young’s moduli and hardness of the MPEAs were respectively within the range of 95-126 GPa and 5.5-6.4 GPa, respectively. In simulated body fluids, the MPEAs had excellent resistance to chloride ion attack due to the fact that the passive films consisted of multiple oxides and the surface possessed large contact angles. Compared with CP-Ti and Ti6Al4V alloy, equiatomic TiHfMo and TiHfMoNb alloys had a desirable combination of pitting and corrosion resistance, wettability, and wear resistance, and can be utilized as potential candidates for biomedical metallic implants.