The effect of warm rolling temperature (500−900 °C) on the microstructure and mechanical properties was investigated for a Ni−W−Co−Ta alloy to achieve excellent strength−plasticity synergy. The results showed that the alloy exhibited high-density dislocations and deformation bands when rolled below 750 °C. The nano-Ni₄W phase precipitated when rolled at 700−900 °C, with the higher deformation temperature, the amount and size of precipitates increased. At 900 °C, dissolution of the precipitated Ni₄W and dynamic recrystallization of the matrix occurred. Consequently, the strength and hardness firstly decreased, then increased, and decreased again as the deformation temperature increased. An excellent strength–plasticity synergy was achieved through the combined effects of precipitation strengthening and deformation twins strengthening of Ni₄W: with a tensile strength of 2010 MPa, a yield strength of 1839 MPa, a microhardness of HV 587, and an elongation of 13.2% when the alloy was warm-rolled at 750 °C.